开元棋牌电脑 |本期目录/Table of Contents|

[1]代贺华,李根林.胶质细胞源性神经营养因子干预视网膜色素变性给药方式的研究进展[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2019,39(4):385-388.[doi:10.13389/j.cnki.rao.2019.0088]
 DAI He-Hua,LI Gen-Lin.Research progress on ophthalmic delivery of glial cell line-derived neurotrophic factor’s intervention in retinitis pigmentosa[J].Recent Advances in Ophthalmology,2019,39(4):385-388.[doi:10.13389/j.cnki.rao.2019.0088]
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胶质细胞源性神经营养因子干预视网膜色素变性给药方式的研究进展(/HTML)
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《开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年4期
页码:
385-388
栏目:
文献综述
出版日期:
2019-04-05

文章信息/Info

Title:
Research progress on ophthalmic delivery of glial cell line-derived neurotrophic factor’s intervention in retinitis pigmentosa
作者:
代贺华李根林
100730 北京市,首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科学与视觉科学重点实验室
Author(s):
DAI He-HuaLI Gen-Lin
Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing 100730,China
关键词:
视网膜色素变性胶质细胞源性神经营养因子给药方式
Keywords:
retinitis pigmentosaglial cell line-derived neurotrophic factorophthalmic delivery
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2019.0088
文献标志码:
A
摘要:
视网膜色素变性(retinitis pigmentosa,RP)的治疗目前仍处于探索阶段。胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)是目前研究中重要的神经营养因子,但其传统给药方式生物利用度相对较低。近年来GDNF安全有效的给药方式成为研究热点,包括经病毒载体或非病毒载体的基因工程法释药技术、经聚合物释放系统释药技术、经细胞移植释药技术、小分子触发器诱导产生GDNF等。本文就GDNF干预RP的给药方式进行综述。
Abstract:
Treatment for retinitis pigmentosa(RP)is still in an exploratory period at present.Glial cell line-derived neurotrophic factor(GDNF)is an important neurotrophic factor,but the conventional ophthalmic delivery of GDNF results in a very low bioavailability,so the safe and effective delivery of GDNF has become the hotspot in recent years,including viral or non-viral mediated gene therapy,polymer-release systems,cell transplantation and small molecules to induce GDNF.This article gives a brief overview on related research progress of new ophthalmic delivery of GDNF intervention in RP.

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备注/Memo

备注/Memo:
国家自然科学基金项目(编号:81271046);北京市自然科学基金项目暨北京市教育委员会科技发展计划重点项目(编号:KZ201510025025)
更新日期/Last Update: 2019-04-15