开元棋牌电脑 |本期目录/Table of Contents|

[1]陈鹤,陆晓和.不同临床背景下角膜新生血管发生机制的研究进展[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2019,39(4):394-397.[doi:10.13389/j.cnki.rao.2019.0090]
 CHEN He,LU Xiao-He.Progress on the mechanisms of corneal neovascularization in different clinical backgrounds[J].Recent Advances in Ophthalmology,2019,39(4):394-397.[doi:10.13389/j.cnki.rao.2019.0090]
点击复制

不同临床背景下角膜新生血管发生机制的研究进展(/HTML)
分享到:

《开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年4期
页码:
394-397
栏目:
文献综述
出版日期:
2019-04-05

文章信息/Info

Title:
Progress on the mechanisms of corneal neovascularization in different clinical backgrounds
作者:
陈鹤陆晓和
510280 广东省广州市,南方医科大学珠江医院眼科
Author(s):
CHEN HeLU Xiao-He
Department of Ophthalmology,Zhujiang Hospital of Southern Medical University,Guangzhou 510280,Guangdong Province,China
关键词:
新生血管性眼病角膜新生血管角膜移植角膜缘干细胞缺乏角膜接触镜相关眼病单纯疱疹病毒性角膜炎
Keywords:
ocular neovascular diseasecorneal neovascularizationcorneal transplantationlimbal stem cell deficiencycontact lens-related diseaseherpes simplex keratitis
分类号:
R772.2
DOI:
10.13389/j.cnki.rao.2019.0090
文献标志码:
A
摘要:
角膜新生血管是一种常见的病理改变,它可在不同的临床背景下发生,破坏角膜免疫赦免、加剧炎症反应、损害视功能。在不同的疾病中,导致角膜新生血管形成的主要因素不同,例如角膜移植中的宿主免疫反应、角膜缘干细胞缺乏中干细胞的维持和分化、接触镜相关眼病中的缺氧、单纯疱疹角膜炎中的病毒感染。探究和理解角膜新生血管在不同临床背景下的发生机制将有助于发展更有针对性的预防和治疗措施。本文对几种主要疾病中角膜新生血管发生机制的研究进展进行综述。
Abstract:
Corneal neovascularization (CNV) is a common pathology and occurs in different corneal diseases.It can breach corneal immune privilege,accelerate inflammation and compromise visual acuity.The leading factor that causes CNV is different in various diseases,for example,the host’s immune response in corneal transplantation,the maintainability and differentiation of stem cells in limbal stem cell deficiency,hypoxia in contact lens-related disease,virus infection in herpes simplex keratitis.Exploration and understanding of the mechanisms of CNV in different diseases will help us develop more targeted measures for prevention and treatment.This article aims to review the mechanisms of CNV in several main diseases.

参考文献/References:

[1] MONGIAT M,ANDREUZZI E,TARTICCHIO G,PAULITTI A.Extracellular matrix,a hard player in angiogenesis[J].Int J Mol Sci,2016,17(11):1822.
[2] LI F,ZHAO S Z.Control of cross talk between angiogenesis and inflammation by mesenchymal stem cells for the treatment of ocular surface diseases[J].Stem Cells Int,2016,2016:7961816.
[3] ABDELFATTAH N S,AMGAD M,ZAYED A A,SALEM H,ELKHANANY A E,HUSSEIN H,et al.Clinical correlates of common corneal neovascular diseases:A literature review[J].Int J Ophthalmol,2015,8(1):182-193.
[4] FEIZI S,AZARI A A,SAFAPOUR S.Therapeutic approaches for corneal neovascularization[J].Eye Vis (Lond),2017,4:28.
[5] QAZI Y,WONG G,MONSON B,STRINGHAM J,AMBATI B K.Corneal transparency:Genesis,maintenance and dysfunction[J].Brain Res Bull,2010,81(2-3):198-210.
[6] VOICULESCU O,VOINEA L,ALEXANDRESCU C.Corneal neovascularization and biological therapy[J].J Med Life,2015,8(4):444-448.
[7] MWAIKAMBO B R,YANG C,ONG H,CHEMTOB S,HARDY P.Emerging roles for the CD36 scavenger receptor as a potential therapeutic target for corneal neovascularization[J].Endocr Metab Immune Disord Drug Targets,2008,8(4):255-272.
[8] AZIMZADE Y,HONG J,MASHAGHI A.Immunophysical analysis of corneal neovascularization:Mechanistic insights and implications for pharmacotherapy[J].Sci Rep,2017,7(1):12220.
[9] CURSIEFEN C,COLIN J,DANA R,DIAZ-LLOPIS M,FARAJ L A,GARCIA-DELPECH S,et al.Consensus statement on indications for anti-angiogenic therapy in the management of corneal diseases associated with neovascularisation:Outcome of an expert roundtable[J].Br J Ophthalmol,2012,96(1):3-9.
[10] ZHONG W,MONTANA M,SANTOSA S M,ISJWARA I D,HUANG Y H,HAN K Y,et al.Angiogenesis and lymphangiogenesis in corneal transplantation-A review[J].Surv Ophthalmol,2017,63(4):453-479.
[11] HOU Y,LE VNH,TOTH G,SIEBELMANN S,HORSTMANN J,GABRIEL T,et al.UV-light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival[J].Am J Transplant,2018:1-12.
[12] DAVILA J R,MIAN S I.Infectious keratitis after keratoplasty[J].Curr Opin Ophthalmol,2016,27(4):358-366.
[13] INOMATA T,MASHAGHI A,Di ZAZZO A,LEE S M,CHIANG H,DANA R.Kinetics of angiogenic responses in corneal transplantation[J].Cornea,2017,36(4):491-496.
[14] PEREZ V L.Visualization of immune responses in the cornea[J].Cornea,2017,36(suppl 1):s5-8.
[15] DI ZAZZO A,TAHVILDARI M,SUBBARAYAL B,YIN J,DOHLMAN T H,INOMATA T,et al.Proangiogenic function of t cells in corneal transplantation[J].Transplantation,2017,101(4):778-785.
[16] KANG B S,KIM M K,WEE W R,OH J Y.Infectious keratitis in limbal stem cell deficiency:Stevens-Johnson syndrome versus chemical burn[J].Cornea,2016,35(1):51-55.
[17] ROSSEN J,AMRAM A,MILANI B,PARK D,HARTHAN J,JOSLIN C,et al.Contact lens-induced limbal stem cell deficiency[J].Ocul Surf,2016,14(4):419-434.
[18] VINCENT S J,LEE G A.Paediatric idiopathic limbal stem cell deficiency[J].Cont Lens Anterior Eye,2017,40(3):195-197.
[19] YIN J,JURKUNAS U.Limbal stem cell transplantation and complications[J].Semin Ophthalmol,2018,33(1):134-141.
[20] LI G,ZHANG Y,CAI S,SUN M,WANG J,LI S,et al.Human limbal niche cells are a powerful regenerative source for the prevention of limbal stem cell deficiency in a rabbit model[J].Sci Rep,2018,8(1):6566.
[21] RAMOS T,SCOTT D,AHMAD S.An update on ocular surface epithelial stem cells:Cornea and conjunctiva[J].Stem Cells Int,2015,2015:601731.
[22] HAN K Y,TRAN J A,CHANG J H,AZAR D T,ZIESKE J D.Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization[J].Sci Rep,2017,7:40548.
[23] LIM P,FUCHSLUGER T A,JURKUNAS U V.Limbal stem cell deficiency and corneal neovascularization[J].Semin Ophthalmol,2009,24(3):139-148.
[24] YAZDANPANAH G,JABBEHDARI S,DJALILIAN A R.Limbal and corneal epithelial homeostasis.[J].Curr Opin Ophthalmol,2017,28(4):348-354.
[25] NOWELL C S,ODERMATT P D,AZZOLIN L,HOHNEL S,WAGNER E F,FANTNER G E,et al.Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction[J].Nat Cell Biol,2016,18(2):168-180.
[26] OUYANG H,XUE Y,LIN Y,ZHANG X,XI L,PATEL S,et al.WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis[J].Nature,2014,511(7509):358-361.
[27] PURBA T S,HASLAM I S,SHAHMALAK A,BHOGAL R K,PAUS R.Mapping the expression of epithelial hair follicle stem cell-related transcription factors LHX2 and SOX9 in the human hair follicle[J].Exp Dermatol,2015,24(6):462-467.
[28] KITAJIMA K,MINEHATA K,SAKIMURA K,NAKANO T,HARA T.In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2[J].Blood,2011,117(14):3748-3758.
[29] GENZ B,THOMAS M,PUTZER B M,SIATKOWSKI M,FUELLEN G,VOLLMAR B,et al.Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells[J].Exp Cell Res,2014,328(2):429-443.
[30] SARTAJ R,CHEE R I,YANG J,WAN P,LIU A,GUAIQUIL V,et al.LIM Homeobox Domain 2 is Required for Corneal Epithelial Homeostasis[J].Stem Cells,2016,34(2):493-503.
[31] ALIPOUR F,KHAHESHI S,SOLEIMANZADEH M,HEIDARZADEH S,HEYDARZADEH S.Contact lens-related complications:A review[J].J Ophthalmic Vis Res,2017,12(2):193-204.
[32] GE J.Ophthalmology[M].Beijing:People’s Medical Publishing House Co,LTD,2015:209.
葛坚.眼科学[M].北京:人民卫生出版社,2015:209.
[33] YEUNG K K,YANG H J,NGUYEN A L,WEISSMAN B A.Critical contact lens oxygen transmissibility and tear lens oxygen tension to preclude corneal neovascularization[J].Eye Contact Lens,2017,44(suppl 1):s291-295.
[34] MOSCHOS M M,NITODA E,GEORGOUDIS P,BALIDIS M,KARAGEORGIADIS E,KOZEIS N.Contact lenses for keratoconus- current practice[J].Open Ophthalmol J,2017,11:241-251.
[35] ROSSEN J,AMRAM A,MILANI B,PARK D,HARTHAN J,JOSLIN C,et al.Contact lens-induced limbal stem cell deficiency[J].Ocul Surf,2016,14(4):419-434.
[36] ARITA R,FUKUOKA S,MORISHIGE N.Meibomian gland dysfunction and contact lens discomfort[J].Eye Contact Lens,2017,43(1):17-22.
[37] PAPAS E.Corneal vascularisation and contact lenses[J].Arch Soc Esp Oftalmol,2006,81(6):309-312.
[38] BOOST M,CHO P,WANG Z.Disturbing the balance:Effect of contact lens use on the ocular proteome and microbiome[J].Clin Exp Optom,2017,100(5):459-472.
[39] PEET D J,KITTIPASSORN T,WOOD J P,CHIDLOW G,CASSON R J.HIF signalling:The eyes have it[J].Exp Cell Res,2017,356(2):136-140.
[40] CHEN P,YIN H,WANG Y,WANG Y,XIE L.Inhibition of VEGF expression and corneal neovascularization by shRNA targeting HIF-1α in a mouse model of closed eye contact lens wear[J].Mol Vis,2012,18:864.
[41] MIEYAL P A,BONAZZI A,JIANG H,DUNN M W,SCHWARTZMAN M L.The effect of hypoxia on endogenous corneal epithelial eicosanoids[J].Invest Ophthalmol Vis Sci,2000,41(8):2170-2176.
[42] WANG L,GONZALEZ S,DAI W,DENG S,LU L.Effect of hypoxia-regulated polo-like kinase 3 (Plk3) on human limbal stem cell differentiation[J].J Biol Chem,2016,291(32):16519-16529.
[43] TSATSOS M,MACGREGOR C,ATHANASIADIS I,MOSCHOS M M,HOSSAIN P,ANDERSON D.Herpes simplex virus keratitis:An update of the pathogenesis and current treatment with oral and topical antiviral agents[J].Clin Exp Ophthalmol,2016,44(9):824-837.
[44] GIMENEZ F,SURYAWANSHI A,ROUSE B T.Pathogenesis of herpes stromal keratitis--a focus on corneal neovascularization[J].Prog Retin Eye Res,2013,33:1-9.
[45] AZHER T N,YIN X,STUART P M.Understanding the role of chemokines and cytokines in experimental models of herpes simplex keratitis[J].J Immunol Res,2017,2017:1-5.
[46] AMBATI B K,PATTERSON E,JANI P,JENKINS C,HIGGINS E,SINGH N,et al.Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barrier[J].Br J Ophthalmol,2007,91(4):505.
[47] SINGH N,TIEM M,WATKINS R,CHO Y K,WANG Y,OLSEN T,et al.Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity[J].Blood,2013,121(20):4242-4249.
[48] SURYAWANSHI A,MULIK S,SHARMA S,REDDY P B,SEHRAWAT S,ROUSE B T.Ocular neovascularization caused by herpes simplex virus type 1 infection results from breakdown of binding between vascular endothelial growth factor a and its soluble receptor[J].J Immunol,2011,186(6):3653-3665.
[49] HE J,NEUMANN D,KAKAZU A,PHAM T L,MUSARRAT F,CORTINA M S,et al.PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection[J].Exp Eye Res,2017,161:153-162.
[50] ZAYED N S A M.Host immune cellular reactions in corneal neovascularization[J].Int J Ophthalmol,2016,9(4):625-633.
[51] GURUNG H R,CARR M M,BRYANT K,CHUCAIR-ELLIOTT A J,CARR D J.Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection[J].Mucosal Immunol,2018,11(1):172-185.
[52] DU H T,DU L L,TANG X L,GE H Y,LIU P.Blockade of MMP-2 and MMP-9 inhibits corneal lymphangiogenesis[J].Graefes Arch Clin Exp Ophthalmol,2017,255(8):1573-1579.
[53] ZAHIR-JOUZDANI F,ATYABI F,MOJTABAVI N.Interleukin-6 participation in pathology of ocular diseases[J].Pathophysiology,2017,24(3):123-131.

相似文献/References:

[1]王军花 高桂平.Avastin不同给药途径对兔角膜新生血管及超微结构的影响[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2012,32(5):.
[2]程文武 江萍 席祖莲 张汉武 訾世莉 聂军 董彩虹.蛹虫草提取物抑制大鼠角膜新生血管的实验研究[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2012,32(5):.
[3]邹文进 刘祖国 刘曼丽 付馨余 赵静博 王松 黄海.多西环素与地塞米松抑制碱烧伤大鼠角膜新生血管的对比研究[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2013,33(8):.
[4]罗杰,胡琦,史学良,等.As2O3 对兔角膜碱烧伤后IL-1β及VCAM-1表达的影响[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2014,34(5):414.[doi:10.13389/j.cnki.rao.2014.0114]
 LUO Jie,HU Qi.SHI Xue-Liang,Ll Dan-Dan,et al.Effects of As2O3 on IL-1β and VCAM-1 expression following corneal alkali burns in rabbits[J].Recent Advances in Ophthalmology,2014,34(4):414.[doi:10.13389/j.cnki.rao.2014.0114]
[5]郝瑞霖,杨炜,张奕霞,等.乙酰半胱氨酸对角膜新生血管形成过程中瘦素和PEDF表达的调节[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2014,34(8):718.[doi:10.13389/j.cnki.rao.2014.0196]
 HAO Rui-Lin,YANG Wei,ZHANG Yi-Xia,et al.Regulative effects of acetylcysteine on leptin and PEDF in corneal neovascularization[J].Recent Advances in Ophthalmology,2014,34(4):718.[doi:10.13389/j.cnki.rao.2014.0196]
[6]修立恒,刘洪涛,曾小平. iNOS对兔角膜碱烧伤后新生血管形成的影响[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2014,34(9):830.[doi:10.13389/j.cnki.rao.2014.0229]
 [J].Recent Advances in Ophthalmology,2014,34(4):830.[doi:10.13389/j.cnki.rao.2014.0229]
[7]徐硕,张红.角膜新生血管药物治疗的最新进展[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2015,35(10):989.[doi:10.13389/j.cnki.rao.2015.0271]
 XU Shuo,ZHANG Hong.Recent advances in drug therapy of corneal neovascularization[J].Recent Advances in Ophthalmology,2015,35(4):989.[doi:10.13389/j.cnki.rao.2015.0271]
[8]王军梅,孙艳,周明明,等.兔角膜碱烧伤后角膜基质注射脐带间充质干细胞的疗效[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2016,36(7):622.[doi:10.13389/j.cnki.rao.2016.0165]
 WANG Jun-Mei,SUN Yan,ZHOU Ming-Ming,et al.Effects of corneal stromal injection of umbilical cord mesenchymal stem cells after rabbit corneal alkali burn[J].Recent Advances in Ophthalmology,2016,36(4):622.[doi:10.13389/j.cnki.rao.2016.0165]
[9]吴艳,叶芬,黄振平.不同浓度KH902对兔碱烧伤后角膜新生血管的抑制作用[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2016,36(8):720.[doi:10.13389/j.cnki.rao.2016.0191]
 WU Yan,YE Fen,HUANG Zhen-Ping.Inhibitive effects of different concentrations of KH902 eye drops on corneal neovascularization after rabbit corneal alkali burn[J].Recent Advances in Ophthalmology,2016,36(4):720.[doi:10.13389/j.cnki.rao.2016.0191]
[10]王玮,徐玲娟,蔡苏博,等.角膜基质及结膜下单次注射康柏西普治疗角膜新生血管的疗效及安全性[J].开元棋牌电脑_开元棋牌一直在维护_开元棋牌怎么对刷,2016,36(8):725.[doi:10.13389/j.cnki.rao.2016.0192]
 WANG Wei,XU Lin-Juan,CAI Su-Bo,et al.Efficacy and safety of one dose intrastromal and subconjunctival conbercept injection for corneal neovascularization[J].Recent Advances in Ophthalmology,2016,36(4):725.[doi:10.13389/j.cnki.rao.2016.0192]

备注/Memo

备注/Memo:
更新日期/Last Update: 2019-04-15